Factorbook is a resource for human and mouse transcription factors, focusing on their binding specificities and regulatory roles in gene expression across cell types. Factorbook integrates public data, especially ENCODE data, to provide a wide-ranging motif catalog and transcription factor binding sites.
Transcription factors (TFs) are pivotal proteins regulating cellular functions by binding to specific DNA sequences. With around 1800 unique TFs in the human genome, they control gene transcription, crucial for processes like development and cell cycle.
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Sequence motifs of transcription factors (TFs) are specific, short DNA sequences that TFs recognize and bind to. These motif sites, typically ranging from 6 to 20 base pairs, are essential for the precise regulation of gene expression. The diversity and specificity of these motifs underlie the complexity of gene regulation.
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Genetic variants in regulatory elements of the human genome play a critical role in influencing traits and disease susceptibility by modifying transcription factor (TF) binding and gene expression. Factorbook offers a comprehensive resource of TF binding motifs and sites, enabling researchers to predict the impact of genetic variants on TF binding and gene regulation, providing valuable insights into the functional consequences of these variants.
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